Trend tests for genetic association using population-based cross-sectional complex survey data
نویسندگان
چکیده
منابع مشابه
Tests for genetic association using family data.
We use likelihood-based score statistics to test for association between a disease and a diallelic polymorphism, based on data from arbitrary types of nuclear families. The Nonfounder statistic extends the transmission disequilibrium test (TDT) to accommodate affected and unaffected offspring, missing parental genotypes, phenotypes more general than qualitative traits, such as censored survival...
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The Cochran-Armitage trend test is a standard procedure in genetic association studies. It is a directed test with high power to detect genetic effects that follow the gene-dosage model. In this paper, the author proposes optimal trend tests for genetic association studies of heterogeneous diseases. Monte-Carlo simulations show that the power gain of the optimal trend tests over the conventiona...
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A common study to investigate gene-environment interaction is designed to be longitudinal and population-based. Data arising from longitudinal association studies often contain missing responses. Naive analysis without taking missingness into account may produce invalid inference, especially when the missing data mechanism depends on the response process. To address this issue in the ana...
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Feuer and Kessler (1989) generalized the McNemar test (1947) to a two sample situation where the hypothesis of interest is that the marginal changes in each of two independent sample's tables are equal. We show two refinements of this test for complex survey data, which require different estimates of variance. In particular, we present these tests along with applications from the Current Popula...
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BACKGROUND Although smokers tend to have a lower body-mass index than non-smokers, smoking may favour abdominal body fat accumulation. To our knowledge, no population-based studies have assessed the relationship between smoking and body fat composition. We assessed the association between cigarette smoking and waist circumference, body fat, and body-mass index. METHODS Height, weight, and wai...
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ژورنال
عنوان ژورنال: Biostatistics
سال: 2009
ISSN: 1465-4644,1468-4357
DOI: 10.1093/biostatistics/kxp035